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CHOLESTEROL 7-ALPHA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Cholesterol 7-alpha-Hydroxylase
Descriptor
Spanish
:
Colesterol 7-alfa-Hidroxilasa
Descriptor
Portuguese
:
Colesterol 7-alfa-Hidroxilase
Synonyms
English
:
CYP7
CYP7A
Cytochrome P-450 CYP7
Tree Number:
D08.244.453.915.200
D08.811.682.690.708.170.915.200
D08.811.682.690.708.783.200
D12.776.422.220.453.915.200
Definition
English
:
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of
CHOLESTEROL
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP7, converts
cholesterol
to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of
BILE
ACIDS.
History Note
English
:
2003 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23193
Unique Identifier:
D002790
Occurrence in VHL
:
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CID-10
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